Millions of people all over the world are identified with mental health disorders and the number today has reached the skyline. To treat this disorder, scientists came across many solutions and one more gets added to the list.
A recent study claims that compounds derived from grapes such as has derived Malvidin-3-O-glucoside (Mal-gluc) and dihydrocaffeic acid (DHCA) anti-depressant properties and may help in curing different types of mental disorders.

Currently available anti-depressants produce provisional re-emissions and later direct to adversative reactions. Moreover, they directly target and affect dopamine and serotonin. Hence, there is a crucial need for finding alternative therapies.

What causes depression?

Irritation of peripheral nervous system is the biggest cause of depression. The immune system helps in defending against any type of diseases and transiting electrical signal between a large number of neurons.

The process involved in deriving polyphenol from grapes:

The preparation consists of polyphenol compound derived from three grapes. This includes Concord grape juice, grape seed extract, and trans-resveratrol. The compound was first tested in mice that showed positive results.

Malvidin-3-O-glucoside and Dihydrocaffeic compounds had an anti-depressing, anti-inflaming effect on the bone marrow of the depression suspected mice. Professor Jun Wang, at Icahn, said, “These compounds can altogether endorse flexibility on phenotypes thereby curbing complete seditious responses.”

After testing these compounds in mice they came to the conclusion that DHCA helps in modulating inflammation and Mal-gluc in synaptic plasticity. This was a successful approach to find a solution to a number of diseases by adopting a way of DNA epigenetic modification against treating depression and various mental disorders.

Future scope of the study remains to find alternative compounds to suppress synaptic maladaptation and inflammation especially for an individual who still don’t react effectively to the currently available treatments.

Research findings and conclusions of this studies were published in Nature Communications journal.

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